Novel Regulators of Cell Mechanotransduction
The quiet influence of Thy-1
Thy-1, and perhaps numerous GPI-linked, integrin binding membrane proteins, have tremendous potential to alter how cells sense and respond to their mechanical environment.
Hijacking the Cell's Mechanotransduction Machinery
Finding the leverage point
A host of intracellular signaling molecules and transcription factors help realize the cell's intended responses to the mechanical microenvironment.
Hey, don't forget the Matrix
Fibronectin is our hyper-elastic friend
Fibronectin and many other ECM proteins exhibit significant molecular deformation under force. Do these deformations drive meaningful altered interactions with cells?
Time is not on our side
The incongruity between acute mechanotransduction and chronic disease progression
How mechanotransduction within cells and the matrix drive lasting changes in tissue remodeling are incompletely understood.
the motley crew
Countless hours, poor pay, and an absent-minded Principal Investigator all qualify these guys as heroes & lab rats!
Jagath brings extensive experience in antibody development based on his time working in the Antibody Engineering and Development Core facility. His research focuses on antibody production as potential therapeutics.
5th Year PhD Candidate
Molecular and Cellular Basis of Disease (MCBD) PhD Program
Riley is studying the potential for mechanical cues and cytokine signaling to impact pericyte participation in tissue regeneration and fibrosis.
Ph.D. & Postdoc (PD)
Ph.D. & Postdoc (PD)
We're all just trying to find happiness
The folks in my lab remind me that we are each on a journey. Sometimes we have detours and sometimes we find ourselves unintentionally in the fast lane. They help me on my journey every day and I hope, in return, I help them find their way too.
My own "regenerative medicine" experiment
The small band of humans that tolerate me
Thankfully a handfull of individuals put up with me and for that I'm very grateful. These folks share a common love for food, travel, and family
Yeah, major driver in my life
I have a healthy love for cooking and eating. I like to cook and eat just about anywhere I am. Eating is good and I particularly like eating at places that take you someplace you've never been before.
National Institutes of Health
3 Postdoc & Fellow-to-Faculty Fellowships
7 Predoctoral MD/PhD & PhD Fellows & Trainees
American Heart Association
2 Postdoc & Predoctoral Fellows